COST EMF - MED (Action BM1309): European network for innovative uses of EMFs in biomedical applications STSM Report: DIELECTRIC PROPERTIES MEASUREMENTS OF AN IN VIVO BREAST TUMOR MODEL
نویسنده
چکیده
The advances in theranostic technologies based on the interaction of electromagnetic fields with biological tissues led to the development of dielectric spectroscopy, with particular attention to the living biological tissue. This STSM aimed to the measurements of the dielectric properties of an original in vivo breast model realized in a rat and simulating the actual condition of a human breast. The model accounts not only fat tissue, but fibrous, lymphatic and vascular components also, to simulate the dis-homogeneity of the human breast. Measurements of complex dielectric permittivity were conducted on in vivo samples with a portable setup, fully validated on reference liquids and ex vivo tissues, particularly suitable to conduct measurements in laboratories dedicated to the animal tests. A. Purpose of the STSM The knowledge of the dielectric properties of tissues is fundamental for the development of theranostic techniques based on the interaction of electromagnetic fields (EMFs) with biological tissues, possibly with the help of targeting paramagnetic nanoconstructs. Up to now, some gaps of knowledge are present in the characterization of dielectric behavior of tissues and tumors [1-6], especially regarding in vivo measurements. In fact it is important to investigate how the irreversible variations (cell degradation, dryness, and temperatures variation, etc.) occurring in biological tissues after their excision from the host can infer the dielectric properties behavior. In this STSM, the dielectric properties of an in vivo breast model developed at the Academy of Sciences of the Czech Republic by Dr. Luca Vannucci were measured in the frequency range of 500 – 3000 MHz. This breast model was developed for hyperthermia studies and it is under study for original model publication.
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تاریخ انتشار 2016